Abinonutra Healty Research

For centuries, the pursuit of longevity has inspired myths, rituals, and remedies across cultures. Today, we know that there is no elixir of eternal youth. Instead, longevity emerges from the interplay between biological mechanisms and the daily choices we make. Advances in molecular biology, nutrition, and lifestyle research suggest that while aging is inevitable, its trajectory is modifiable. Aging is shaped by multiple processes: genomic instability, telomere shortening, mitochondrial dysfunction, and chronic inflammation, often referred to as “inflammaging.” These mechanisms accelerate damage within cells and tissues, reducing resilience over time. The study of longevity, therefore, is less about stopping the clock and more about understanding these drivers and finding ways to mitigate their impact. Decades of population studies show that diet, exercise, sleep, and stress management have measurable effects on lifespan and healthspan. Calorie balance, regular physical activity, and restorative sleep each interact with molecular pathways that regulate energy metabolism, oxidative stress, and immune function. Small choices—such as walking daily—accumulate over decades to influence biological aging. Nutrition offers another avenue for supporting longevity. In recent years, attention has focused on molecules that directly support energy metabolism and redox balance. For instance, Nicotinamide Riboside (NR) replenishes NAD+ levels, vital for mitochondrial function, while L-Ergothioneine acts as a rare antioxidant with unique stability under oxidative stress. At AbinoNutra, we see longevity not as a promise of miracles but as the product of rigorous science and intentional choices. That is why our formulations highlight compounds like NR and quercetin, reflecting decades of research into mitochondrial health and cellular senescence. By combining evidence-based ingredients with the recognition that lifestyle matters, we aim to empower individuals to support their own biology in the journey of aging. Longevity is not a myth, nor is it guaranteed. It is the outcome of complex biological processes informed by the choices we make every day. As research continues to reveal how molecules like NAD+ precursors and antioxidants interact with lifestyle practices, the path forward becomes clearer: healthy aging is not about chasing legends but about aligning science with intentional living. By AbinoNutra Biological Research Staff 1.Chmielewski PP, Data K, Strzelec B, et al. Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions. Aging Dis. 2024;16(4):1853-1877. 2.Baechle JJ, Chen N, Makhijani P, Winer S, Furman D, Winer DA. Chronic inflammation and the hallmarks of aging. Mol Metab. 2023;74:101755. 3.Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. J Gerontol A Biol Sci Med Sci. 2023;78(12):2435-2448. 4.Zapata-Pérez R, Wanders RJA, van Karnebeek CDM, Houtkooper RH. NAD(+) homeostasis in human health and disease. EMBO Mol Med. 2021;13(7):e13943.  

Few daily rituals are as universal as drinking coffee or tea. Beyond their cultural significance and comforting taste, these beverages have long intrigued scientists for another reason: their association with health and longevity. At the heart of this connection lies a diverse group of molecules called polyphenols—plant-derived compounds with powerful antioxidant and signaling properties. Polyphenols are not just antioxidants in the classical sense of neutralizing free radicals. They also act as modulators of cellular signaling, influencing pathways related to inflammation, mitochondrial health, and metabolic regulation. For example, compounds such as catechins in green tea or chlorogenic acids in coffee have been studied for their roles in improving insulin sensitivity and protecting cardiovascular function. Epidemiological research has shown that moderate coffee consumption is associated with reduced risk of chronic conditions, including type 2 diabetes, certain cancers, and neurodegenerative diseases. While caffeine often takes the spotlight, polyphenols such as chlorogenic acids may be equally important contributors. Their ability to lower oxidative stress and inflammation may help explain why coffee drinkers sometimes show improved survival outcomes. Tea, especially green tea, has been extensively studied for its catechin content—most notably epigallocatechin gallate (EGCG). These molecules appear to influence not only oxidative balance but also autophagy, the cellular recycling process critical for longevity. Observational studies in Asian populations have suggested that habitual tea consumption is linked to lower mortality rates and healthier aging trajectories. While coffee and tea are iconic sources, polyphenols are found throughout the diet—from berries and apples to onions and herbs. In the context of longevity research, one compound that draws increasing attention is Quercetin. Known as a flavonoid polyphenol, quercetin has been studied for its potential to reduce senescent cell burden and improve vascular health. Interestingly, AbinoNutra incorporates quercetin into its formulations, reflecting a shared scientific interest in its promise for supporting healthy aging. What unites coffee, tea, and targeted nutritional ingredients is their ability to modulate oxidative stress and mitochondrial function. Chronic oxidative stress accelerates cellular damage, while mitochondrial dysfunction is a hallmark of aging. Polyphenols, alongside compounds like L-Ergothioneine (ET), may serve as cellular shields, buffering against stress and preserving energy production. This convergence highlights a broader strategy: supporting longevity by reinforcing the resilience of our cells. From a practical standpoint, enjoying coffee or tea in moderation can be part of a longevity-supporting lifestyle. But beverages alone are not the whole story. Integrating polyphenol-rich foods with evidence-based supplements may help create a more consistent foundation for cellular health. The AbinoNutra approach is to bridge this gap—acknowledging the wisdom of everyday habits while providing additional tools to strengthen resilience at the molecular level. By AbinoNutra Biological Research Staff 1.Kobylińska Z, Biesiadecki M, Kuna E, Galiniak S, Mołoń M. Coffee as a Source of Antioxidants and an Elixir of Youth. Antioxidants (Basel). 2025;14(3):285. 2.Prasanth MI, Sivamaruthi BS, Chaiyasut C, Tencomnao T. A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients. 2019;11(2):474. 3.Jomova K, Alomar SY, Valko R, et al. Flavonoids and their role in oxidative stress, inflammation, and human diseases. Chem Biol Interact. 2025;413:111489. 4.Liu Y, Fang M, Tu X, et al. Dietary Polyphenols as Anti-Aging Agents: Targeting the Hallmarks of Aging. Nutrients. 2024;16(19):3305. Published 2024 Sep 29.  

Aging is not only about the passage of time; it is also deeply shaped by how our bodies and minds respond to stress. In recent decades, scientists have discovered that chronic stress accelerates cellular aging through mechanisms such as oxidative stress, inflammation, and disruption of circadian rhythms. This has led to a growing interest in interventions like mindfulness and meditation—practices that may reduce stress and support healthier aging. From a molecular perspective, stress hormones such as cortisol can disrupt mitochondrial energy production and increase the generation of reactive oxygen species (ROS). Over time, this oxidative burden damages DNA, proteins, and cell membranes. Studies have linked high perceived stress to shorter telomeres—the “protective caps” of our chromosomes—suggesting that psychological strain leaves measurable biological marks. Mindfulness and meditation work by shifting the body away from chronic sympathetic activation toward parasympathetic balance. Physiologically, this translates into lower cortisol levels, reduced inflammation, and improved heart rate variability. Neuroimaging studies also suggest that regular meditation strengthens brain networks involved in emotion regulation and attention, indirectly buffering the stress response. Yet, stress management is not limited to the mind. At AbinoNutra, our research emphasizes the importance of pairing psychological practices with cellular resilience. For example, antioxidants like L-Ergothioneine (ET) may complement mindfulness by reducing oxidative stress within mitochondria, while NAD+ precursors such as Nicotinamide Riboside (NR) support the energy systems that stress often depletes. In this way, lifestyle and targeted nutrition are not competitors but collaborators in the pursuit of healthy longevity. What does this mean in everyday life? Incorporating even a few minutes of mindfulness practice daily may help reduce the biological burden of stress. Combined with nutritional strategies that reinforce mitochondrial health and redox balance, the impact can be amplified. Our perspective is not that one tool replaces another, but that integration—mind and cell, behavior and biochemistry—offers the most promising path forward. Managing stress is more than feeling calm—it is an intervention at the cellular level that may influence how we age. By uniting psychological tools like mindfulness with biochemical support explored in AbinoNutra’s work, we envision a model of aging research that is multidimensional, holistic, and deeply human. By AbinoNutra Biological Research Staff 1.Prakash RS, De Leon AA, Patterson B, Schirda BL, Janssen AL. Mindfulness and the aging brain: a proposed paradigm shift. Front Aging Neurosci. 2014;6:120. Published 2014 Jun 24. 2.Aghajanyan V, Bhupathy S, Sheikh S, Nausheen F. A Narrative Review of Telomere Length Modulation Through Diverse Yoga and Meditation Styles: Current Insights and Prospective Avenues. Cureus. 2023;15(9):e46130. Published 2023 Sep 28. 3.Bertozzi B, Tosti V, Fontana L. Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. Gerontology. 2017;63(1):13-19. 4.Brenner C. Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution. J Exp Neurosci. 2019;13:1179069519869679. Published 2019 Aug 13.  

When discussing health and longevity, exercise is often the first lifestyle factor to be mentioned. Many people immediately think of marathons or heavy weight training, as if only high-intensity workouts truly matter. Yet, a growing body of research reminds us that even light activity can have profound effects on lifespan and healthspan. Light activity refers to movements that slightly raise the heart rate without causing significant fatigue—such as walking, gentle yoga, gardening, or household chores. Epidemiological studies consistently show that individuals who remain lightly active in daily life have lower risks of all-cause mortality and cardiovascular disease compared to those who are sedentary. Notably, the transition from “no activity” to “some activity” often yields the most dramatic health benefits. Possible Mechanisms Why does light activity matter so much? Several mechanisms may help explain: Cardiovascular improvement: Regular activity supports vascular elasticity, lowers blood pressure, and improves circulation. Metabolic flexibility: Light exercise enhances insulin sensitivity and reduces glucose variability. Anti-inflammatory and antioxidant effects: Consistent low-intensity activity has been shown to lower chronic inflammation and oxidative stress. Musculoskeletal support: Even simple walking helps slow muscle loss and maintain bone density. Neural benefits: Light activity correlates with reduced risk of cognitive decline, potentially by promoting neuroplasticity. For older adults, individuals with mobility limitations, or those without established exercise routines, light activity is particularly crucial. Walking, gardening, or even stretching at home can serve as practical tools for healthy aging. These activities not only reduce the risk of chronic disease but also provide psychological benefits, such as reducing loneliness and improving sleep. Longevity research conveys a simple truth: exercise does not have to be intense to be meaningful. Even light activity, if maintained consistently, can exert profound effects at the molecular, organ, and whole-body levels. For people of all ages, the key is taking the step from “sedentary” to “active”—even a small one may shift the trajectory of health. By AbinoNutra Biological Research Staff 1.Lee IM, Paffenbarger RS Jr. Associations of light, moderate, and vigorous intensity physical activity with longevity. The Harvard Alumni Health Study. Am J Epidemiol. 2000;151(3):293-299. 2.Guan Y, Yan Z. Molecular Mechanisms of Exercise and Healthspan. Cells. 2022;11(5):872. Published 2022 Mar 3. 3.Miko HC, Zillmann N, Ring-Dimitriou S, Dorner TE, Titze S, Bauer R. Auswirkungen von Bewegung auf die Gesundheit [Effects of Physical Activity on Health]. Gesundheitswesen. 2020;82(S 03):S184-S195. 4.Izquierdo M, Merchant RA, Morley JE, et al. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021;25(7):824-853.  

The relationship between diet and lifespan has long fascinated biologists and medical researchers. From simple organisms like yeast and worms to mice and even primates, scientists have observed that reducing caloric intake or altering feeding patterns can influence the pace of aging. These findings have gradually filtered into public discourse, making calorie restriction (CR) and intermittent fasting (IF) two key terms in the conversation around health and longevity. Calorie restriction is not simply about “eating less.” It refers to a long-term reduction in total calorie intake (typically 20–40%) without causing malnutrition. In laboratory settings, CR has been shown to extend lifespan in yeast, worms, flies, and mice, while improving metabolic health. In primates, results are more nuanced: some studies show lifespan extension, while others highlight improvements mainly in healthspan rather than maximum lifespan. In humans, long-term randomized trials are difficult to conduct, but evidence suggests that CR can improve glucose control, lower inflammatory markers, and support cardiovascular health. Intermittent fasting does not primarily focus on reducing total caloric intake but instead alters the timing of food consumption. Common patterns include: 16:8: fasting for 16 hours each day and eating within an 8-hour window; Alternate-day fasting (ADF): fasting or significantly reducing calories every other day; 5:2 diet: reducing calories on two days per week while eating normally on the other five. In animal studies, IF has been shown to activate autophagy, improve insulin sensitivity, and reduce inflammation. In humans, evidence suggests IF may aid in weight management, metabolic health, and potentially improve sleep and cognition. However, its long-term effects remain to be fully clarified. CR and IF are often compared because both influence energy metabolism. They share similarities: Both may reduce oxidative stress and inflammation; Both improve insulin sensitivity and metabolic health; Both may slow aging by activating autophagy and supporting mitochondrial function. The difference lies in their approach: CR is a continuous reduction in energy intake, whereas IF emphasizes the rhythm of eating. From a practical standpoint, many find IF easier to adhere to, while long-term CR can be challenging in daily life. Although evidence is still incomplete, CR and IF provide strong clues about how diet may influence aging. They highlight the idea that not only what we eat, but also how we eat matters. However, these approaches are not suitable for everyone—for example, older adults, pregnant women, or individuals with specific metabolic conditions. Looking ahead, with advances in epigenetics and metabolomics, we may one day identify who benefits most from CR or IF. Diet is not the sole determinant of lifespan, but it is a powerful variable we can actively influence. Whether through calorie restriction or intermittent fasting, scientists are gradually uncovering how eating patterns interact with molecular mechanisms of aging. This is not only a frontier in longevity research but also an inspiration for daily life: a balanced, moderate, and scientifically informed diet may be the closest thing we have to an anti-aging strategy. By AbinoNutra Biological Research Staff 1.Most J, Tosti V, Redman LM, Fontana L. Calorie restriction in humans: An update. Ageing Res Rev. 2017;39:36-45. 2.Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46-58. 3.Green CL, Lamming DW, Fontana L. Molecular mechanisms of dietary restriction promoting health and longevity. Nat Rev Mol Cell Biol. 2022;23(1):56-73. 4.Dominguez LJ, Veronese N, Baiamonte E, et al. Healthy Aging and Dietary Patterns. Nutrients. 2022;14(4):889.  

When we think about dietary supplements, few people consider the inactive components, commonly referred to as excipients, that make these products functional, stable, and safe to consume. Excipients are more than inert fillers; they serve critical roles in ensuring proper tablet or capsule formation, improving stability, and enhancing the bioavailability of active ingredients. In the case of AbinoNutra supplements, three widely used excipients are microcrystalline cellulose, magnesium stearate, and silicon dioxide. Each contributes uniquely to the quality and reliability of the final product. Microcrystalline Cellulose Microcrystalline cellulose (MCC) is derived from purified plant cellulose and is widely used in pharmaceuticals and supplements as a tablet filler and binder. It has several important functions: Tablet formation: MCC provides structural integrity, allowing powders to compress into stable tablets without crumbling. Flowability and consistency: It improves the uniformity of the mixture, ensuring that each tablet contains an accurate dose of active ingredients. Non-reactive nature: MCC is chemically inert, meaning it does not react with vitamins, minerals, or other active molecules. In essence, MCC acts as the “skeleton” of the tablet. Magnesium Stearate Magnesium stearate is a salt formed from stearic acid and magnesium. It functions primarily as a lubricant in supplement manufacturing: Reducing friction: It prevents powders from sticking to machinery during tablet compression or capsule filling. Improving tablet quality: Magnesium stearate helps maintain smooth surfaces and uniform shapes, reducing breakage during packaging and transport. Safety and tolerance: At the levels used in dietary supplements, magnesium stearate is considered safe and non-toxic. While small amounts are used—typically less than 2% of tablet weight—its presence is essential for consistent production and reliable dosing. Silicon Dioxide (SiO₂) Silicon dioxide (SiO₂), also called colloidal silica, is used in supplements as an anti-caking agent and flow enhancer: Preventing clumping: SiO₂ absorbs trace moisture and keeps powders free-flowing. Maintaining stability: By preventing aggregation, it helps ensure uniform mixing and accurate dosing. Compatibility: Silicon dioxide is chemically inert and safe for human consumption at the levels used in supplements. It ensures that powders and granules behave predictably during manufacturing and storage. Excipients are not just fillers—they are critical enablers for delivering active ingredients safely and effectively. Without them, tablets could crumble, powders could clump, and dosage could vary. Without them, the active ingredients could not reach you safely, accurately, and consistently. Understanding excipients helps consumers appreciate the scientific rigor behind supplement formulation. By AbinoNutra Biological Research Staff 1.Alyami H, Dahmash E, Bowen J, Mohammed AR. An investigation into the effects of excipient particle size, blending techniques and processing parameters on the homogeneity and content uniformity of a blend containing low-dose model drug. PLoS One. 2017;12(6):e0178772. Published 2017 Jun 13. 2.Thoorens G, Krier F, Leclercq B, Carlin B, Evrard B. Microcrystalline cellulose, a direct compression binder in a quality by design environment--a review. Int J Pharm. 2014;473(1-2):64-72. 3.Zarmpi P, Flanagan T, Meehan E, Mann J, Fotaki N. Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties. AAPS J. 2020;22(4):75. Published 2020 May 21. 4.Yoo NK, Jeon YR, Choi SJ. Determination of Two Differently Manufactured Silicon Dioxide Nanoparticles by Cloud Point Extraction Approach in Intestinal Cells, Intestinal Barriers and Tissues. Int J Mol Sci. 2021;22(13):7035. Published 2021 Jun 29.