Quercetin: A Flavonoid with Potential for Healthy Aging
Quercetin is a naturally occurring flavonol, a subclass of flavonoids found in many fruits, vegetables, tea, and grains. While it has been widely studied for its antioxidant properties, emerging research suggests that quercetin may do more than simply neutralize free radicals—it could support cellular health and contribute to longevity.
With aging populations worldwide, scientists are increasingly interested in compounds that may help maintain metabolic balance, protect against oxidative stress, and potentially reduce the burden of senescent cells. Quercetin has emerged as a candidate molecule worthy of further study.
In human nutrition, quercetin acts as an antioxidant, anti-inflammatory agent, and modulator of various cellular signaling pathways. It is abundant in onions, apples, kale, grapes, and green tea, making it a compound we encounter in everyday diets.
Chemically, quercetin’s structure allows it to scavenge reactive oxygen species (ROS) and influence enzymes like sirtuins, which are linked to DNA repair, metabolic regulation, and cellular longevity.
One of the most intriguing aspects of quercetin research is its role as a senolytic agent. Senescent cells accumulate with age and secrete inflammatory molecules that can impair tissue function. Animal studies suggest that quercetin, especially when combined with compounds like dasatinib, can reduce senescent cell burden, improving tissue function and metabolic markers.
Although human trials are still limited, early data indicate intermittent quercetin supplementation is safe and may positively influence cellular senescence markers. Quercetin is generally considered safe at dietary levels and supplement doses up to 1000 mg/day. Some individuals may experience mild gastrointestinal discomfort. Long-term effects and interactions with medications are still being investigated.
Human clinical trials, though limited, support its potential role in reducing inflammation, supporting cardiovascular health, and potentially influencing markers of cellular aging.
By AbinoNutra Biological Research Staff
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